Monday, October 20, 2014
(Refreshments served at 10:45am in HSCI-224)
Fig: The X-ray structures of the wild-type peptide (KVAELVHFL) and two mutants (KVAEIVHFL and KVAELVWFL)
Controlling and eradicating an unprecedented HIV/AIDS pandemic will require a better surveillance tool and improved vaccine design. Here we demonstrate how mathematical and computational tools originating from statistical physics can be used to advance HIV research. An effective HIV vaccine must contain antigens that recognize as many HIV peptides as possible, and the surface morphology of peptide-MHC (pMHC) complexes is one of the key factors controlling immune response breadth. Our design for predicting pMHC surface morphology assembles homology-based models and all-atom molecular dynamics simulations. Once a functional HIV vaccine is implemented, monitoring HIV incidence, the number of newly infected people, is necessary to evaluate its efficacy. Our lab has focused on developing HIV genomic incidence assays utilizing signatures embedded in an individualís HIV sequence population and quantifying the amount of evolution as a fingerprint of infection duration. Furthermore, mathematical modeling has allowed us to extend our accuracy in determining infection duration for recently infected individuals. Taken together, analytical approaches are becoming indispensable components to medical research.
See the colloquium schedule and its archive of previous talks
Colloquia are scheduled to start Mondays at 11:15am sharp in Peterson Hall 2, Room 110 (PH2-110, map). Refreshments are served from 10:45am to 11:05am in Room HSCI-224 (next to the department office) and everyone is invited to mingle with faculty and students!
We acknowledge with gratitude donations and support from the following present sponsors:
We also acknowledge with gratitude our past donors: The Forty-Niner Shops, Inc., The Northrop Grumman Foundation, Sandra Dana, Anonymous.
If you wish to support the Colloquium, please contact the colloquium coordinator or the department chair. Thank you!
|Date||Title||Speaker and Affiliation|
|June 2||Development of Micro-Devices for Intra-Cellular Recordings in Awake Active Brains||M. Barbic, HHMI|
|September 8||Physics Deparment Meet & Mix||Faculty and
|September 15||Density Functional Theory: A great physics success story||Kieron Burke, UC Irvine|
|September 22||BME/Medical Physics; Assisted management of cardiopulmonary diseases||Christopher Druzgalski, CSULB|
|September 29||Radiationless Decay Studied by Time- Dependent Density Functional Theory||Enrico Tapavicza, CSULB|
|October 6||Electronic correlations in multi-orbital systems and iron based superconductors||Elena Bascones: ICMM, CSIC|
|October 13||Searches for Particle Dark Matter||Tim Tait, UCI|
|October 20||Theoretical Approaches towards HIV Vaccine Designs and Prevention Efforts||Ha Youn Lee, USC|
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