Skip to Local Navigation
Skip to Content
California State University, Long Beach
Print this pageAdd this page to your favoritesSelect a font sizeSelect a small fontSelect a medium fontSelect a large font
 
Department News and Colloquium

Physics & Astronomy Colloquium at CSU Long Beach

Colloquium

Theoretical Approaches towards HIV Vaccine Designs and Prevention Efforts

Ha Youn Lee
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California

Monday, October 20, 2014
11:15am, HSCI-103
(Refreshments served at 10:45am in HSCI-224)


Fig: The X-ray structures of the wild-type peptide (KVAELVHFL) and two mutants (KVAEIVHFL and KVAELVWFL)

Controlling and eradicating an unprecedented HIV/AIDS pandemic will require a better surveillance tool and improved vaccine design. Here we demonstrate how mathematical and computational tools originating from statistical physics can be used to advance HIV research. An effective HIV vaccine must contain antigens that recognize as many HIV peptides as possible, and the surface morphology of peptide-MHC (pMHC) complexes is one of the key factors controlling immune response breadth. Our design for predicting pMHC surface morphology assembles homology-based models and all-atom molecular dynamics simulations. Once a functional HIV vaccine is implemented, monitoring HIV incidence, the number of newly infected people, is necessary to evaluate its efficacy. Our lab has focused on developing HIV genomic incidence assays utilizing signatures embedded in an individualís HIV sequence population and quantifying the amount of evolution as a fingerprint of infection duration. Furthermore, mathematical modeling has allowed us to extend our accuracy in determining infection duration for recently infected individuals. Taken together, analytical approaches are becoming indispensable components to medical research.

See the colloquium schedule and its archive of previous talks

Colloquia are scheduled to start Mondays at 11:15am sharp in Peterson Hall 2, Room 110 (PH2-110, map). Refreshments are served from 10:45am to 11:05am in Room HSCI-224 (next to the department office) and everyone is invited to mingle with faculty and students!

Coordinator:

For information and suggestions about the colloquium please contact the colloquium coordinator:
Prof. Prashanth Jaikumar, Phone: 562-985-5592, Email: pjaikuma@csulb.edu

Directions to Campus

  • Access to Campus
  • Campus Maps
  • Parking on campus: contact the coordinator of the colloquium. If not reachable, call the department office (562) 985-7925. If none of these are available at the time you need information, call (562) 985-4146 or go to the drive-through information booth at the main campus entrance (on Beach Drive, near the crossing to Bellflower).
  • Walk (or ask for a ride on an on-campus shuttle) to the department office: Hall of Sciences, Room 220 (HSCI-220). The coordinator will provide the necessary informations.
  • Any question or problem: call the colloquium coordinator or the department office (562) 985-7925.

Colloquia Sponsors:

We acknowledge with gratitude donations and support from the following present sponsors:

  • H.E. and H.B. Miller
  • Benjamin Carter
  • The American Physical Society
  • Anonymous

We also acknowledge with gratitude our past donors: The Forty-Niner Shops, Inc., The Northrop Grumman Foundation, Sandra Dana, Anonymous.

If you wish to support the Colloquium, please contact the colloquium coordinator or the department chair. Thank you!

Academic Year 2014-2015

Date Title Speaker and Affiliation
June 2 Development of Micro-Devices for Intra-Cellular Recordings in Awake Active Brains M. Barbic, HHMI
September 8 Physics Deparment Meet & Mix Faculty and
Students
September 15 Density Functional Theory: A great physics success story Kieron Burke, UC Irvine
September 22 BME/Medical Physics; Assisted management of cardiopulmonary diseases Christopher Druzgalski, CSULB
September 29 Radiationless Decay Studied by Time- Dependent Density Functional Theory Enrico Tapavicza, CSULB
October 6 Electronic correlations in multi-orbital systems and iron based superconductors Elena Bascones: ICMM, CSIC
October 13 Searches for Particle Dark Matter Tim Tait, UCI
October 20 Theoretical Approaches towards HIV Vaccine Designs and Prevention Efforts Ha Youn Lee, USC
October 27
November 3
November 10
November 17
November 24
December 1
December 8
December 10

Colloquia Schedule

[back to top]